Detalhe da pesquisa
1.
Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.
Cell
; 169(1): 148-160.e15, 2017 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28340340
2.
Transcriptome-wide analysis of PGC-1α-binding RNAs identifies genes linked to glucagon metabolic action.
Proc Natl Acad Sci U S A
; 117(36): 22204-22213, 2020 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32848060
3.
Autophagy mediates hepatic GRK2 degradation to facilitate glucagon-induced metabolic adaptation to fasting.
FASEB J
; 34(1): 399-409, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31914606
4.
Regulation of Hepatic Metabolism, Recent Advances, and Future Perspectives.
Curr Diab Rep
; 19(10): 98, 2019 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31494755
5.
The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator.
J Biol Chem
; 291(20): 10635-45, 2016 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27022023
6.
The response to high CO2 levels requires the neuropeptide secretion component HID-1 to promote pumping inhibition.
PLoS Genet
; 10(8): e1004529, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25101962
7.
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism.
Cell Metab
; 35(8): 1356-1372.e5, 2023 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37473754
8.
Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans.
Proc Natl Acad Sci U S A
; 106(10): 4024-9, 2009 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19237558
9.
Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production.
J Med Chem
; 64(2): 980-990, 2021 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33434430
10.
Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency.
Cancer Res
; 80(16): 3215-3221, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32606000
11.
Sensing, physiological effects and molecular response to elevated CO2 levels in eukaryotes.
J Cell Mol Med
; 13(11-12): 4304-18, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19863692
12.
Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans.
Sci Rep
; 9(1): 18251, 2019 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31796806
13.
Insulin regulation of gluconeogenesis.
Ann N Y Acad Sci
; 1411(1): 21-35, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28868790
14.
Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting.
Cell Metab
; 25(2): 428-437, 2017 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28089567
15.
Targeting hepatic glucose metabolism in the treatment of type 2 diabetes.
Nat Rev Drug Discov
; 15(11): 786-804, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27516169
16.
Pharyngeal pumping inhibition and avoidance by acute exposure to high CO2 levels are both regulated by the BAG neurons via different molecular pathways.
Worm
; 4(1): e1008898, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26430557
17.
Molecular pathophysiology of hepatic glucose production.
Mol Aspects Med
; 46: 21-33, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26549348
18.
Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis.
Mol Biol Cell
; 23(4): 543-52, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22171324
19.
Evolutionary conserved role of c-Jun-N-terminal kinase in CO2-induced epithelial dysfunction.
PLoS One
; 7(10): e46696, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23056407
20.
The physiological and molecular effects of elevated CO2 levels.
Cell Cycle
; 9(8): 1528-32, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20372066